Note: There is no scientific evidence suggesting that body weight significantly influences the effects of psilocybin. Research indicates that within weight-adjusted groups (20 mg/70 kg and 30 mg/70 kg) and fixed dose groups, no significant associations were found between the subjective effects of psilocybin and demographic variables including body weight or sex. This observation holds across a broad spectrum of body weights (49 to 113 kg), indicating that body weight does not markedly affect the subjective experiences induced by psilocybin. Despite this, we recommend the following dosing guidelines as a “safe start” for individuals exploring psilocybin, aiming to provide a cautious framework for those new to or familiar with its use.